解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:OBJECTIVE:To study the effects of mental stress on the absorption kinetics of insulin and on glucose homeostasis and lipolysis in insulin-dependent diabetes mellitus (IDDM). RESEARCH DESIGN AND METHODS:Nine IDDM patients were exposed to the Stroop color word conflict test (CWT) during 40 min after injection of 125I-la...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.14.11.1006
更新日期:1991-11-01 00:00:00
abstract:OBJECTIVE:To determine whether reducing triglyceride concentrations in humans reduces serum insulin levels and consider the implications of this for the insulin resistance of hypertriglyceridemia. RESEARCH DESIGN AND METHODS:Insulin and glucose levels were determined during an oral glucose tolerance test (OGTT) in 14 ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.14.11.1077
更新日期:1991-11-01 00:00:00
abstract:OBJECTIVE:To study the relationship between the prevalence of impaired glucose tolerance (IGT) and non-insulin-dependent diabetes mellitus (NIDDM) across populations of the Pacific Ocean region to assess whether variability in those two proportions followed some predictable pattern related to modernization of life-styl...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.14.11.968
更新日期:1991-11-01 00:00:00
abstract:OBJECTIVE:The efficacy of topical phenytoin in the treatment of diabetic foot ulcers was evaluated in a controlled inpatient study. RESEARCH DESIGN AND METHODS:Fifty patients were treated with topical phenytoin, and 50 patients matched for age, sex, and ulcer areas, depth, chronicity, and infection were dressed with d...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.14.10.909
更新日期:1991-10-01 00:00:00
abstract:OBJECTIVE:Acarbose inhibits alpha-glucosidases of the small intestine and thus delays glucose release from complex carbohydrates. Therefore, its efficacy and acceptability as a first-line drug in non-insulin-dependent diabetes mellitus (NIDDM) insufficiently treated with diet alone was tested in a randomized double-bli...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.14.8.732
更新日期:1991-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the possibility of replacing quantitative albumin excretion rate (AER) measurements with rapid screening tests for microalbuminuria. RESEARCH DESIGN AND METHODS:Dipstick-negative specimens from 363 consecutive insulin-dependent diabetes mellitus (IDDM) and 46 non-insulin-dependent diabetes mellit...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.14.7.591
更新日期:1991-07-01 00:00:00
abstract::The prevalence of obesity among Hispanic American populations is generally greater than among white populations in the United States. Among Mexican Americans, the prevalence of obesity was higher than among either Cuban Americans or Puerto Ricans. It is well known that the prevalence of diabetes increases with increas...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.14.7.691
更新日期:1991-07-01 00:00:00
abstract::The association of obesity with hypertension has been amply demonstrated in cross-sectional, longitudinal, and dietary-intervention studies, but the mechanisms remain enigmatic. Both conditions are independently characterized by similar metabolic alterations, i.e., glucose intolerance, dyslipoproteinemia, elevated ser...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.14.6.470
更新日期:1991-06-01 00:00:00
abstract:OBJECTIVE:To determine the role of height and glycosylated hemoglobin in abnormal nerve conduction in pediatric patients with insulin-dependent (type I) diabetes mellitus. RESEARCH DESIGN AND METHODS:Sixty-six pediatric patients (aged 6.3-18.2 yr) with a duration of diabetes from 4 to 8.5 yr but free of clinical neuro...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.14.5.386
更新日期:1991-05-01 00:00:00
abstract:OBJECTIVE:We wanted to determine whether obesity, abdominal fat distribution, and physical inactivity act similarly and independently as risk factors for noninsulin-dependent diabetes mellitus (NIDDM) and impaired glucose tolerance (IGT) in Hindu and Muslim Asian Indians, African-origin Creoles, and Chinese Mauritians....
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.14.4.271
更新日期:1991-04-01 00:00:00
abstract:OBJECTIVE:To assess the frequency and possible risk indicators of severe hypoglycemia in insulin-dependent (type I) diabetic patients with impaired kidney function. RESEARCH DESIGN AND METHODS:Retrospective follow-up examination of case subjects and control subjects with mean follow-up periods of 2.9 and 1.3 yr, respe...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.14.4.344
更新日期:1991-04-01 00:00:00
abstract::Borderline hypertension, a condition in which the blood pressure oscillates between normal and high values, is a predictor of future more severe hypertension. Pathophysiologically, borderline hypertension is different from established hypertension. A large proportion of such patients have elevated cardiac output and a...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.14.3.249
更新日期:1991-03-01 00:00:00
abstract:OBJECTIVE:To determine the effectiveness of an intervention program designed to improve blood glucose awareness. RESEARCH DESIGN AND METHODS:Eight young-adult outpatients (mean age 22 yr) and six adolescent inpatients (mean age 14.5 yr) with insulin-dependent diabetes mellitus participated in the intervention program....
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.14.1.1
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:This study evaluated the possibility of inhibiting protein glycosylation in vivo with vitamin E. RESEARCH DESIGN AND METHODS:Two groups of 10 insulin-requiring diabetic patients, matched for duration of disease and metabolic control, received daily vitamin E supplementation of 1200 and 600 mg, respectively, ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.14.1.68
更新日期:1991-01-01 00:00:00
abstract::Intensive insulin therapy is best defined as a comprehensive system of diabetes management with the patient and management team as partners. The system is directed at improvement of glycemia and patient well-being. Glycemic targets should be individually defined. Frequent self-monitoring of blood glucose, probably at ...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.13.12.1265
更新日期:1990-12-01 00:00:00
abstract::Our objective was to define glomerular filtration rate (GFR) and renal plasma flow (RPF) in Black Americans with non-insulin-dependent diabetes mellitus (NIDDM). This was a cross-sectional study of 71 Black NIDDM patients with diagnosed diabetes duration from 1 mo to 21 yr. Hyperglycemia was regulated and stabilized b...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.13.11.1186
更新日期:1990-11-01 00:00:00
abstract::The goal of this study was to evaluate a program of resistance weight training on cardiovascular risk factors, blood glucose management, and overall strength in diabetic subjects. A randomized crossover design was performed on eight male type I (insulin-dependent) diabetic subjects (mean +/- SD age 31 +/- 3.5 yr, heig...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.13.10.1039
更新日期:1990-10-01 00:00:00
abstract::Due to the inherent pharmacokinetic properties of available insulins, normoglycemia is rarely, if ever, achieved in insulin-dependent diabetic patients without compromising their quality of life. Subcutaneous insulin absorption is influenced by many factors, among which the associated state of insulin (hexameric) in p...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.13.9.923
更新日期:1990-09-01 00:00:00
abstract::The goal of this study was to investigate whether treatment with bezafibrate improves glucose tolerance in non-insulin-dependent diabetes mellitus (NIDDM). The study included 37 NIDDM patients with HbA1 concentrations greater than 8.5% and normal kidney and liver function who were being treated with diet alone or diet...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.13.8.855
更新日期:1990-08-01 00:00:00
abstract::This study describes and characterizes a putative sulfonylurea receptor. The radioligand used was [3H]glipizide (9 Ci/mmol). The beta-cell plasma membranes were derived from a transplantable rat insulinoma generated by subcutaneous injection of RINm5F cells and purified by ultracentrifugation on a 15-55% sucrose gradi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.13.3.2
更新日期:1990-08-01 00:00:00
abstract::The acute effect of sulfonylurea drugs during long-term treatment was evaluated in two separate studies. In the first study, the levels of plasma glucose, insulin, and C-peptide were measured after intake of 10 mg glyburide alone or together with a standardized mixed meal in 10 non-insulin-dependent diabetes mellitus ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.13.3.26
更新日期:1990-08-01 00:00:00
abstract::Cyclosporin and other immunosuppressive agents have been proposed as a preventive treatment against the development of insulin-dependent diabetes mellitus (IDDM) in relatives at increased risk for the disease, based on the understanding that its etiology is an ongoing process of autoimmune beta-cell destruction. We us...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,评审
doi:10.2337/diacare.13.7.776
更新日期:1990-07-01 00:00:00
abstract::Combination sulfonylurea-insulin therapy for patients with diabetes mellitus has been evaluated by numerous investigators with various experimental designs. Much of the data are conflicting, and clear conclusions do not seem justified. Insulin-sulfonylurea therapy is probably not clinically useful in most patients wit...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.13.6.667
更新日期:1990-06-01 00:00:00
abstract::A film test for the rapid detection of plasma/serum 3-hydroxybutyrate (3-OHB) has been developed. The film contains NAD, nitro blue tetrazolium, 3-OHB dehydrogenase, and diaphorase, and the surface is coated with modified biomembrane and can detect 50-1500 microM 3-OHB within 2-3 min. One drop or 50 microliters of pla...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.13.5.522
更新日期:1990-05-01 00:00:00
abstract::There was a need to design a questionnaire that could accurately assess the activity patterns of Native Americans to evaluate the relationship between physical activity and diabetes. Such a questionnaire was developed and implemented into the data collection scheme of the prospective Pima Indian Study of Arizona. The ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.13.4.401
更新日期:1990-04-01 00:00:00
abstract::Adjustment algorithms for conventional insulin therapy must be tested for safety and efficacy before clinical implementation. We did this by computer simulation. Accordingly, a computer simulator of human intermediary metabolism created 10 randomly chosen diabetic subjects for study. All were well defined with respect...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.13.4.393
更新日期:1990-04-01 00:00:00
abstract::Regulation of gene transcription is a major action of insulin. Most of the greater than 20 examples of this effect involve the stimulation of transcription, but a few involve an inhibition. The inhibition of transcription of the phosphoenolpyruvate carboxykinase (PEPCK) gene has been studied in detail. Most of this ef...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.13.3.327
更新日期:1990-03-01 00:00:00
abstract::To quantify the association of abnormal glucose tolerance with hypertension and postural hypotension, 2480 men and women aged 50-89 yr from a defined population were evaluated by oral glucose tolerance and measurements of supine, seated, and standing blood pressure. In both sexes, adults with impaired glucose toleranc...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.13.2.119
更新日期:1990-02-01 00:00:00
abstract::Coronary heart disease is the leading cause of death among patients with non-insulin-dependent diabetes mellitus (NIDDM). NIDDM patients have a high frequency of dyslipidemia, which along with obesity, hypertension, and hyperglycemia may contribute significantly to accelerated coronary atherosclerosis. Because risk fa...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.13.2.153
更新日期:1990-02-01 00:00:00
abstract::Compared with control subjects, non-insulin-dependent diabetes mellitus (NIDDM) subjects had both quantitative and qualitative abnormalities in blood insulin and glucose concentrations. The purpose of this study was to determine whether and to what extent normally observed multiphasic patterns of insulin and glucose r...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.12.10.709
更新日期:1989-11-01 00:00:00
abstract::Intranasal glucagon can raise blood glucose levels in healthy subjects. The aims of this study were to 1) compare the hyperglycemic effect of intranasal and intramuscular glucagon in healthy subjects and type I (insulin-dependent) diabetes patients during euglycemic conditions and 2) test the efficacy of intranasal an...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.12.9.604
更新日期:1989-10-01 00:00:00
abstract::Secondary failure to oral hypoglycemic agents (OHAs) is a possible outcome for non-insulin-dependent diabetes mellitus (NIDDM) patients and poses a serious therapeutic problem. In this study, we evaluated the effect of adding a single bedtime low-dose NPH insulin injection to the previous ineffective sulfonylurea ther...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.12.8.582
更新日期:1989-09-01 00:00:00
abstract::The etiology of impotence in the diabetic population has not been clearly defined. To assess this problem, 24 impotent diabetic subjects, 21 nonimpotent diabetic subjects, and 10 subjects with psychogenic impotence were compared with nocturnal monitoring of penile tumescence and rigidity, penile arterial blood flow, a...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.12.7.449
更新日期:1989-07-01 00:00:00
abstract::The relationship of two aspects of family life to metabolic control were examined as part of a longitudinal study of school-aged children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). Glycosylated hemoglobin level was the primary index of metabolic control; weight-adjusted insulin dosage served as a...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.12.6.409
更新日期:1989-06-01 00:00:00
abstract::This study examined the effect of age on the posthepatic delivery of oral glucose (PHDG) during steady-state conditions. We used an intravenous-oral modification of the euglycemic insulin-clamp technique to assess PHDG in six men aged 24-39 yr (young) and eight men aged 65-83 yr (old). Each subject underwent two studi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.12.6.394
更新日期:1989-06-01 00:00:00
abstract::In a patient with hyperthyroidism and newly diagnosed insulin-dependent diabetes mellitus (IDDM), insulin action and clearance were studied before the initiation of antithyroid treatment and at 3-mo intervals for 1 yr thereafter. The sequential euglycemic clamp technique (5 mM) was used with insulin infusion rates of ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.12.5.319
更新日期:1989-05-01 00:00:00
abstract::Whereas self-monitoring of blood glucose (SMBG) is the recommended source of information on which to make self-care decisions, patients frequently use estimates of their own blood glucose (BG). This study evaluated whether patients with insulin-dependent diabetes mellitus (IDDM) could learn to improve accuracy of BG e...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.12.5.313
更新日期:1989-05-01 00:00:00
abstract::In this study, 18 type I (insulin-dependent) diabetic subjects aged 22-35 yr (mean age 29.3) and within 10 yr of diagnosis (mean 7.7) performed a battery of cognitive and psychomotor tasks under conditions of hypoglycemia (50 mg/dl), normoglycemia (100 mg/dl), and hyperglycemia (300 mg/dl). Blood glucose levels during...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.12.3.193
更新日期:1989-03-01 00:00:00
abstract::In children with insulin-dependent diabetes mellitus (IDDM), deterioration in metabolic control frequently occurs during early adolescence. To prevent this predictable increase in blood glucose levels, we randomly assigned young adolescents with IDDM to an intervention based on problem solving with self-monitoring of ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.12.3.179
更新日期:1989-03-01 00:00:00
abstract::Recently, there has been increasing interest toward the liberalization of sucrose in the diets of individuals with non-insulin-dependent diabetes mellitus (NIDDM). However, there is evidence from several well-controlled prospective studies demonstrating that the consumption of moderate amounts of sucrose may result in...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.12.1.62
更新日期:1989-01-01 00:00:00